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Woojin Jung(AIRS Medical, Seoul, Republic of Korea), JeeYoung Kim(Department of Radiology, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, 03312), Jingyu Ko(AIRS Medical, Seoul, Republic of Korea), Geunu Jeong(AIRS Medical, Seoul, Republic of Korea)& Hyun Gi Kim(Department of Radiology, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, 03312)
European radiology (2022)
This study aimed to accelerate the 3D magnetization–prepared rapid gradient-echo (MPRAGE) sequence for brain imaging through the deep neural network (DNN).
This retrospective study used the k-space data of 240 scans (160 for the training set, mean ± standard deviation age, 93 ± 80 months, 94 males; 80 for the test set, 106 ± 83 months, 44 males) of conventional MPRAGE (C-MPRAGE) and 102 scans (77 ± 74 months, 52 males) of both C-MPRAGE and accelerated MPRAGE. All scans were acquired with 3T scanners. DNN was developed with simulated-acceleration data generated by under-sampling. Quantitative error metrics were compared between images reconstructed with DNN, GRAPPA, and E-SPIRIT using the paired t-test. Qualitative image quality was compared between C-MPRAGE and accelerated MPRAGE reconstructed with DNN (DNN-MPRAGE) by two readers. Lesions were segmented and the agreement between C-MPRAGE and DNN-MPRAGE was assessed using linear regression.
Accelerated MPRAGE reduced scan times by 38% compared to C-MPRAGE (142 s vs. 320 s). For quantitative error metrics, DNN showed better performance than GRAPPA and E-SPIRIT (p < 0.001). For qualitative evaluation, overall image quality of DNN-MPRAGE was comparable (p > 0.999) or better (p = 0.025) than C-MPRAGE, depending on the reader. Pixelation was reduced in DNN-MPRAGE (p < 0.001). Other qualitative parameters were comparable (p > 0.05). Lesions in C-MPRAGE and DNN-MPRAGE showed good agreement for the dice similarity coefficient (= 0.68) and linear regression (R2 = 0.97; p < 0.001).
DNN-MPRAGE reduced acquisition time by 38% and revealed comparable image quality to C-MPRAGE.